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Index > Protein center > GSTA4(Gene name) > Human
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  • GSTA4 (Gene name),
  • Glutathione S-transferase A4 (Protein name ),  GSTA4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GSTA4;
    Protein name:
    Glutathione S-transferase A4;
    Alternative:
    Glutathione S-transferase A4-4;GST class-alpha member 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    222
    Sequence:
    50:
    MAARPKLHYP | NGRGRMESVR | WVLAAAGVEF | DEEFLETKEQ | LYKLQDGNHL | 
    100:
    LFQQVPMVEI | DGMKLVQTRS | ILHYIADKHN | LFGKNLKERT | LIDMYVEGTL | 
    150:
    DLLELLIMHP | FLKPDDQQKE | VVNMAQKAII | RYFPVFEKIL | RGHGQSFLVG | 
    200:
    NQLSLADVIL | LQTILALEEK | IPNILSAFPF | LQEYTVKLSN | IPTIKRFLEP | 
    222:
    GSKKKPPPDE | IYVRTVYNIF | RP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Glutathione S-transferase A4
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    E0609h
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    ELISA Kit for Human Glutathione S-transferase A4
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    E0609r
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    ELISA Kit for Human Glutathione S-transferase A4
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    E0609m
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    ELISA Kit for Human Glutathione S-transferase A4
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    E0609b
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    Packing:
    96T
    CLIA Kit for Human Glutathione S-transferase A4
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    U0609m
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    96T
    CLIA Kit for Human Glutathione S-transferase A4
    Cat.:
    U0609r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glutathione S-transferase A4
    Cat.:
    U0609h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glutathione S-transferase A4
    Cat.:
    U0609b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Glutathione S-transferase A4
    Polyclonal Antibody for Human Glutathione S-transferase A4
    Cat.:
    P0609Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glutathione S-transferase A4
    Cat.:
    P0609Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glutathione S-transferase A4
    Cat.:
    P0609Rb-r
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Glutathione S-transferase A4
    Monoclonal Antibody for Human Glutathione S-transferase A4
    Monoclonal Antibody for Human Glutathione S-transferase A4
    Monoclonal Antibody for Human Glutathione S-transferase A4
    Protein for Human Glutathione S-transferase A4
    Protein for Human Glutathione S-transferase A4
    Protein for Human Glutathione S-transferase A4
    Protein for Human Glutathione S-transferase A4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation."
      Hubatsch I. , Ridderstrom M. , Mannervik B.
      Biochem. J.330:175-179(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4."
      Board P.G.
      Biochem. J.330:827-831(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Identification of a novel human glutathione S-transferase using bioinformatics."
      Liu S. , Stoesz S.P. , Pickett C.B.
      Arch. Biochem. Biophys.352:306-313(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "The 4-HNE metabolizing GST isozyme hGSTA4-4 is expressed in human heart, pancreas, and skeletal muscle."
      Piper J.T. , Awasthi Y.C.
      Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Heart.
      tissue: Pancreas.
      tissue: Skeletal muscle.
    5. 5.
      "Genomic organization, 5'-flanking region and chromosomal localization of the human glutathione transferase A4 gene."
      Desmots F. , Rauch C. , Henry C. , Guillouzo A. , Morel F.
      Biochem. J.336:437-442(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      NIEHS SNPs program
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-100 AND ALA-163
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Esophageal carcinoma.
    9. 9.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Uterus.
    12. 12.
      "Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products."
      Bruns C.M. , Hubatsch I. , Ridderstroem M. , Mannervik B. , Tainer J.A.
      J. Mol. Biol.288:427-439(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) IN COMPLEX WITH 2-IODOBENZYL GLUTATHIONE;CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF TYR-212;SUBUNIT
    13. 13.
      "Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal."
      Balogh L.M. , Le Trong I. , Kripps K.A. , Shireman L.M. , Stenkamp R.E. , Zhang W. , Mannervik B. , Atkins W.M.
      Biochemistry49:1541-1548(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG;CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF TYR-9
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